Genetic mapping in hypertension
نویسندگان
چکیده
منابع مشابه
Genetic mapping of a modifier locus affecting hypertension in soluble guanylate cyclase α1 deficient mice
Background We previously reported that male mice deficient in the a1 subunit of the NO receptor soluble guanylate cyclase (sGCa1 -/mice), an important nitric oxide (NO) receptor, are hypertensive [1]. The phenotype depends on the genetic background: sGCa1 -/mice on a 129S6 (S6) background (sGCa1 ) but not on a C57BL/6 (B6) background (sGCa1 ) develop hypertension [2]. These findings suggest tha...
متن کاملChromosomal mapping of the genetic basis of hypertension and renal disease in FHH rats.
This study examined the genetic basis for hypertension and renal disease phenotypes in Fawn Hooded hypertensive (FHH) rats using chromosome substitution strains (consomic rats) in which each of the 20 autosomes as well as the X and Y chromosomes were transferred from the normal Brown Norway (BN) rat onto the FHH genetic background. Male and female rats of each of the parental and consomic strai...
متن کاملGenetic mapping of a modifier locus affecting hypertension in soluble guanylate cyclase a1 deficient mice
Background We previously reported that male mice deficient in the a1 subunit of the NO receptor soluble guanylate cyclase (sGCa1 -/mice), an important nitric oxide (NO) receptor, are hypertensive [1]. The phenotype depends on the genetic background: sGCa1 -/mice on a 129S6 (S6) background (sGCa1 ) but not on a C57BL/6 (B6) background (sGCa1 ) develop hypertension [2]. These findings suggest tha...
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The complex nature of hypertension makes identifying the pathophysiology and its genetic contributions a challenging task. One powerful approach for the genetic dissection of blood pressure regulation is studying inbred rat models of hypertension, as they provide natural allele variants but reduced heterogeneity (both genetic and etiologic). Furthermore, the detailed physiologic studies to whic...
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Constructing genetic maps is a prerequisite for most in-depth genetic studies of an organism. The problem of constructing reliable genetic maps for any organism can be considered as a complex optimization problem with both discrete and continuous parameters. This paper shows how genetic algorithms can been used to tackle this problem on simple pedigree. The approach is embodied in an hybrid alg...
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ژورنال
عنوان ژورنال: Journal of Vascular Surgery
سال: 1992
ISSN: 0741-5214
DOI: 10.1016/0741-5214(92)90757-y